Synonyms/Common Names/Related Substances:

• 4-Androstene-3,17-dione, 4-androstenedione, anabolic steroid, andro, Andro-Gen®, andros, androstene, prohormones, steroid, testosterone.

Clinical Bottom Line/Effectiveness

Brief Background:

• Androstenedione, or "andro," is a testosterone prohormone. It is naturally found in some plant matter and is produced in the gonads and adrenal glands of all mammals.
• Testosterone prohormones are marketed as testosterone-enhancing and muscle-building nutritional supplements. Clinical research has shown that oral androstenedione increases circulating testosterone and estradiol in men (1); however, studies have yet to demonstrate any anabolic effect or increases in libido or sexual performance attributable to these supplements.
• The use of androstenedione may theoretically increase the risk of serious health problems due to its conversion into hormones with androgenic and estrogenic properties in the body, as well as possibly resulting in masculizing or feminizing effects. Supplementation with testosterone prohormones is associated with dyslipidemia and may potentially contribute to cancerous cell growth. Due to the lack of proven benefits and the potential for harmful effects, androstenedione has been banned for over-the-counter sales by the U.S. Food and Drug Administration (FDA) since 2004. However, synthetic androstenedione has recently become increasingly obtainable in many countries due to widespread availability via the Internet.
• The American Academy of Pediatrics, the Endocrine Society, the American Medical Association, and other health professional groups have cautioned against the use of androgenic and anabolic steroids and their precursors due to potential long-term adverse health consequences. Androstenedione has been banned by the International Olympics Committee, the National Collegiate Athletic Association, the National Basketball Association, the National Football League, the World Natural Body Building Federation, and the World Anti-Doping Agency.

Dosing/Toxicology

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Precautions/Contraindications

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Interactions

Most herbs and supplements have not been thoroughly tested for interactions with other herbs, supplements, drugs, or foods. The interactions listed below are based on reports in scientific publications, laboratory experiments, or traditional use. You should always read product labels. If you have a medical condition, or are taking other drugs, herbs, or supplements, you should speak with a qualified healthcare provider before starting a new therapy.

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Mechanism of Action

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History

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Evidence Table

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Evidence Discussion

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Products Studied

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Author Information

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References

Natural Standard developed the above evidence-based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to www.naturalstandard.com. Selected references are listed below.

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